inflammatory breast cancer — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1493	Chrysosplenol D		IL Receptor , NF-κB , JNK
	Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.		IL Receptor , NF-κB , JNK
TN2269	Tetramethylcurcumin		Apoptosis , STAT
	Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also inhibits colony formation in soft agar, cell invasion, and e...		Apoptosis , STAT
T2655	CEP-37440	CEP37440	FAK , ALK
	CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).		FAK , ALK
T15017	CU-T12-9		TLR
	CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activat...		TLR
T6917	Oleuropein		Apoptosis , Aromatase , ROS , PPAR
	Oleuropein is an antioxidant polyphenol isolated from olive leaf.		Apoptosis , Aromatase , ROS , PPAR
TN2883	3',4'-Dimethoxyflavone		Others , PARP
	3',4'-Dimethoxyflavone is a standard compound of flavonoids with numerous medicinal activities.		Others , PARP
T67924	ABzOH
	ABzOH is a benzoic acid derivative, similar in structure to non-steroidal anti-inflammatory drugs such as aspirin, with anti-inflammatory, anti-tumor and anti-proliferative effects. ABzOH can not only inhibit the express...
TN1222	26-Deoxyactein	27-Deoxyactein,23-epi-26-Deoxyactein	NOS , CDK , NO Synthase
	23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can in...		NOS , CDK , NO Synthase
T72968	ZINC00640089		Akt
	ZINC00640089 is a selective lipid carrier protein-2 (LCN2) inhibitor. ZINC00640089 inhibited cell proliferation and cell viability, and reduced AKT phosphorylation in SUM149 cells. ZINC00640089 can be used to study infla...		Akt
T3418	Demethylzeylasteral	Demethylzeylasteral (T-96)	Apoptosis , UGT
	Demethylzeylasteral (T-96), isolated from Tripterygium wilfordii, has anti-inflammatory, immunosuppressive and anti-tumor activities. It inhibits the invasion of triple-negative breast cancer by blocking the TGF-β signal...		Apoptosis , UGT
T6S1683	Demethoxycurcumin	Curcumin II,Desmethoxycurcumin,Monodemethoxycurcumin	Apoptosis , Antioxidant , Antibacterial , Autophagy
	1. Demethoxycurcumin (Desmethoxycurcumin) has antioxidant activity. 2. Demethoxycurcumin has anti-inflammatory activity. 3. Demethoxycurcumin has anti-proliferative activity. 4. Demethoxycurcumin has anti-acanthamoebic e...		Apoptosis , Antioxidant , Antibacterial , Autophagy
T7032	Eupatorin		Others , P450
	Eupatorin has antiproliferative and antiangiogenic effects. Eupatorin has antiproliferative and cytostatic effects on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. Eupatorin-induced cell death is ...		Others , P450
T2966	Beta-Sitosterol	Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost	Apoptosis , Lipase , Endogenous Metabolite
	Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol foun...		Apoptosis , Lipase , Endogenous Metabolite
T5S0661	Koumine		Others
	1. Koumine can treat the diabetic neuropathy. 2. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. 3. Koumine has a significant analgesic effect in rodent behavioral models of infla...		Others
T4S0969	Obtusifolin		Antioxidant , NF-κB
	1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be...		Antioxidant , NF-κB
TN6062	1,3,9-Trimethyluric acid
	1,3,9-Trimethyluric acid exhibits in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the ran...
TN4038	Eupatolide		TNF , NOS , NF-κB , ROS , MAPK , Akt , COX , DNA/RNA Synthesis , Nrf2 , PDGFR , NO Synthase , Prostaglandin Receptor , Autophagy
	Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast cancer cells.
T78149	ZINC00784494		Others
	ZINC00784494, a specific Lipocalin-2 (LCN2) inhibitor, impedes cell proliferation and viability while diminishing AKT phosphorylation in SUM149 cells, showing promise for research on inflammatory breast cancer (IBC) [1].		Others
TN5280	(-)-Zeylenol	Zeylenol	Apoptosis
	(-)-Zeylenol (Zeylenol) is a natural product derived from the stems of the Uvaria grandiflora, showing anti-inflammatory, antifeedant and antitumor biological activity, acting by inhibiting the synthesis or release of mu...		Apoptosis
T70928	CB-1158-analog
	CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vi...